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Dr Rajan Rehan, interventional and structural heart disease cardiologist at One Heart Centre in Sydney (North Shore, Hills District, Inner West, CBD)

Dr Rajan Rehan

Coronary and Structural Heart Disease | Consultant Interventional Cardiologist
MBBS | MPH | PhD | FRACP | FCSANZ | FASE

Clinical Profile

Education & Training

Research

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Clinical Profile

Dr Rajan Rehan is a consultant interventional cardiologist with subspecialty expertise in complex percutaneous coronary intervention (PCI), coronary physiology, angina with non-obstructive coronary arteries (ANOCA/INOCA), and transcatheter structural heart intervention. He has a particular focus on invasive coronary function testing and the diagnosis and management of ANOCA and INOCA.

His interventional practice encompasses intravascular imaging-guided procedures using optical coherence tomography (OCT) and intravascular ultrasound (IVUS), coronary physiology assessment including fractional flow reserve (FFR) and coronary flow reserve (CFR), and calcium modification techniques including intravascular lithotripsy (IVL/shockwave), rotational atherectomy, and excimer laser coronary atherectomy (ELCA). He has extensive experience in high-risk PCI cases, including those requiring mechanical circulatory support.

Dr Rehan is an experienced structural heart interventionalist with expertise in transcatheter aortic valve implantation (TAVI), transcatheter mitral and tricuspid valve therapies, left atrial appendage occlusion (LAAO), and patent foramen ovale (PFO) closure. He performs procedures at North Shore Private Hospital, Mater Hospital, and Macquarie University Hospital.

Education & Training

Dr Rehan completed his medical degree at Bond University, Queensland, followed by a Master of Public Health at the University of Sydney. He undertook Basic Physician Training and Advanced Cardiology Training at Royal Prince Alfred Hospital, Sydney, where he was awarded Fellowship of the Royal Australasian College of Physicians (FRACP) in 2021.

Dr Rehan completed his PhD at the University of Sydney between 2022 and 2025, with doctoral research focused on coronary microvascular dysfunction and invasive testing in ANOCA, supported by a National Health and Medical Research Council (NHMRC) Postgraduate Scholarship. Following the completion of his PhD, he undertook dual Interventional Cardiology Fellowships at St Thomas’ Hospital and Royal Brompton Hospital in London.

He holds Fellowship of the Cardiac Society of Australia and New Zealand (FCSANZ), Fellowship of the American Society of Echocardiography (FASE), and Level A CT Coronary Angiography accreditation. Dr Rehan holds a Senior Clinical Lecturer appointment at the Faculty of Medicine and Health, University of Sydney, and is actively involved in supervising and mentoring medical students, junior doctors, and cardiology trainees.

Research

Dr Rehan’s research focuses on coronary microvascular dysfunction, ANOCA/INOCA, and coronary vasomotor disorders. His work has been published in journals including JACC: Cardiovascular Interventions, Circulation: Cardiovascular Interventions, Heart, and the Journal of Clinical Investigation. He maintains research collaborations with investigators at Stanford University, the University of Sydney, and centres across the United Kingdom and Europe, supported by competitive grant funding.

He has been recognised with the Australia and New Zealand Endovascular Therapies (ANZET) Early Career Research Award (2023) and was named a Ralph Reader Prize finalist at the Cardiac Society of Australia and New Zealand Annual Scientific Meeting (2024).

Selected Publications

Rehan R, Wong C, Weaver J, et al. Multi-vessel Coronary Function Testing Increases Diagnostic Yield in Patients with Angina and Nonobstructive Coronary Arteries. JACC Cardiovasc Interv. 2024;17:1091–1102. https://doi.org/10.1016/j.jcin.2024.03.007

This multicentre study demonstrated that testing all three major coronary arteries — rather than the left coronary artery alone — significantly increases the diagnostic yield of invasive coronary function testing in ANOCA patients. The findings have directly influenced international testing protocols and guidelines.

Rehan R, Khandkar C, Wong CCY, et al. Diagnostic Validity of Acetylcholine Provocation Protocols in the Evaluation of Coronary Artery Spasm in Patients With ANOCA. Circulation: Cardiovascular Interventions. https://doi.org/10.1161/CIRCINTERVENTIONS.124.015339

This study rigorously evaluated the diagnostic validity of incremental acetylcholine dosing protocols used to provoke coronary artery spasm, providing important evidence to standardise invasive testing methodology across international centres.

Rehan R, Wong CCY, Weaver J, et al. Impact of Nitroglycerin Administration on Acetylcholine Provocation Testing in ANOCA. JSCAI. https://doi.org/10.1016/j.jscai.2024.102015

This study examined how the routine administration of nitroglycerin — commonly given prior to coronary angiography — affects the results of acetylcholine provocation testing, with important implications for test accuracy and patient preparation protocols.

Rehan R, Virk S, Wong C, et al. Intracoronary Thrombolysis in ST-elevation Myocardial Infarction: A Systematic Review and Meta-Analysis. Heart. 2024;110(15):988–996. https://doi.org/10.1136/heartjnl-2024-324078

This landmark meta-analysis of 12 randomised controlled trials involving nearly 2,000 patients demonstrated that adjunctive intracoronary thrombolysis at the time of primary PCI in STEMI improves myocardial perfusion parameters without increasing bleeding risk, supporting its use in selected patients.

Rehan R, Wong C, Cooke C, Weaver J, Jain P, Adams M, Ng M, Yong A. Prevalence of Coronary Vasomotor Disorders in Patients with Angina and Nonobstructive Coronary Arteries: A Sydney Experience. Heart Lung Circ. 2024;33(9):1297–1306. https://doi.org/10.1016/j.hlc.2024.02.020

This study reported the first Australian prevalence data for coronary vasomotor disorders in ANOCA patients, finding abnormalities in the majority of those tested and highlighting the critical need to expand access to functional coronary angiography across Australia and New Zealand.